Op-brai130323 1..10
نویسندگان
چکیده
*These authors contributed equally to this work. Present address: Department of Neurology, The Royal London Hospital (Barts and the London NHS Trust), Whitechapel Road, Whitechapel, London E1 1BB, UK and Basildon and Thurrock University Hospitals NHS Foundation Trust, Nethermayne, Essex SS16 5NL, UK Present address: Department of Neurology and Division of Neuroradiology, University Hospital Basel, Switzerland, Petersgraben 4, 4031 Basel, Switzerland Present address: Department of Neurology, University of Miami, Miami FL, USA
منابع مشابه
Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.
Osteopetrotic (op/op) mutant mice suffer from congenital osteopetrosis due to a severe deficiency of osteoclasts. Furthermore, the total number of mononuclear phagocytes is extremely low in affected mice. Serum, 11 tissues, and different cell and organ conditioned media from op/op mice were shown to be devoid of biologically active colony-stimulating factor 1 (CSF-1), whereas all of these prepa...
متن کاملOpposite Categories and Contravariant Functors
The opposite category of a category, contravariant functors and duality functors are defined. Next we state the proposition (1) the objects of C, the morphisms of C, the cod-map of C, the dom-map of C, (the composition of C),the id-map of C is a category. Let us consider C. The functor C op yielding a strict category is defined by the condition (Def. 1). (Def. 1) C op = the objects of C, the mo...
متن کاملCSF-1 deficiency in mice results in abnormal brain development.
Colony stimulating factor-1 (CSF-1) was initially identified as a growth factor for mononuclear phagocytes. This study examines the role of CSF-1 in the development of the central nervous system (CNS). CSF-1 treatment of neurons cultured from embryonic brain promoted survival and process outgrowth in a dose-dependent manner. By contrast, CSF-1 treatment of neurons cultured from the osteopetroti...
متن کاملSpleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice.
Osteoclasts are generated from monocyte/macrophage-lineage precursors in response to colony-stimulating factor 1 (CSF-1) and receptor activator of nuclear factor-κB ligand (RANKL). CSF-1-mutated CSF-1(op/op) mice as well as RANKL(-/-) mice exhibit osteopetrosis (OP) caused by osteoclast deficiency. We previously identified RANKL receptor (RANK)/CSF-1 receptor (CSF-1R) double-positive cells as o...
متن کاملDelayed hematopoietic development in osteopetrotic (op/op) mice
Changes in structure, cellularity, hematopoietic progenitor cell and macrophage content, and osteoclast activity were investigated in the hematopoietic organs of the colony-stimulating factor 1(CSF-1)-less osteopetrotic (op/op) mouse. The data indicated that op/op mice undergo an age-related hematopoietic recovery and resolution of osteopetrosis, suggesting that the hematopoietic system has the...
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